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Complicating the issue is that cells of the osteoblast lineage are the source of RANKL, OPG, and the WNT inhibitor sclerostin lasix for afib To expand the clinical indications of HDACi drugs, we developed novel boron containing prodrugs of belinostat, one of which efficiently releases active through a cascade of reactions in cell culture and demonstrates activities comparable to against a panel of cancer cell lines
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